A recurrent disease may assume the form of a local relapse within the area of the removed tumor (or in the uterus after radiotherapy) or in the neighborhood through extension of the neoplastic process or metastasis. Recurrences are asymptomatic in approximately 30% of patients and diagnosed during a routine check-up. In 35–40% of patients, vaginal bleeding is the first symptom, whereas 16% of women complain about pelvic pain. It must be remembered that urinary disorders may also be the first manifestation of a local recurrence. Until recently, patients with recurrences in a previously irradiated site were not candidates for a repeated radiotherapy mainly because of organs at risk, and more precisely – because of the dose deposited in these organs during the primary treatment. Currently, the dynamic development of new planning and treatment techniques using external-beam radiation makes it possible to consider re-irradiation in selected cases. However, planning and conducting such a treatment is difficult and time-consuming. It requires highly specialized radiotherapy techniques and an individual approach. This article presents a patient with a disease recurrence in the vaginal stump after comprehensive treatment and discusses elements that need to be taken into consideration for repeated radiotherapy to be planned and conducted.