Introduction: Cancer is a very difficult experience for every person who had to face it. The sense of coherence (SOC) is the factor that has an influence on the ability to cope with stress. People with strong SOC are able to use their potential resources in a better way. These resources help patients in their struggle for health. The aim of the paper was to define the relation between the level of the sense of coherence and preferred styles of dealing with difficult situations in women diagnosed with cancer of the genital organs, as a predictor in the struggle with the disease. Material and methods: The research was conducted among 73 women diagnosed with cancer of the genital organs, who were hospitalized in Gynecologic Oncology Clinic in Oncology Center in Bydgoszcz. The sense of coherence was assessed using Life Orientation Questionnaire by Antonovsky (SOC-29) and preferred styles of coping with stress in a difficult situation were tested using CISS questionnaire by Endler and Parker. Results: It was demonstrated that women diagnosed with cancer of the genital organs do not differ from one another in the level of the sense of coherence, and global SOC levels were average. The women gained the highest results in manageability, followed by the feeling of meaningfulness and comprehensibility which obtained the lowest results. The most frequent style was the evasion one. The patients with a high SOC level preferred the style focused on the problem. Rarely did they choose emotional or evasion styles in dealing with the problem. Conclusions: Defining the level of the sense of coherence may have an impact on the care of patients. It may also influence education in neoplastic disease.