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Possible usage of the blood serum concentration measurements of sHLA-G and sRCAS1 in women treated surgically for vulvar cancer as an indicator of the status of the tumor microenvironment

Paweł Blecharz1, Joanna Skręt-Magierło2, Paweł Basta3, Marek Grabiec4, Małgorzata Walentynowicz4, Zbigniew Kojs1, Andrzej Skręt2, Łukasz Wicherek3,4

Affiliacja i adres do korespondencji
CURR. GYNECOL. ONCOL. 2009, 7 (3), p. 192-198
Streszczenie

Introduction: The suppression of the immune system constitutes a crucial event in the development of malignancy. Assessment of the blood serum concentration levels of sRCAS1 and sHLA-G may demonstrate the suppressive influence of cancer cells on the immune system as these proteins are involved in the evasion of immune system surveillance by cancer cells. Since, in some cases, surgery may restore proper immune system activity, we aimed to measure the blood serum concentration levels of both these proteins over the course of the applied therapy. Material and methods: We measured the sRCAS1 and sHLA-G blood serum concentration levels in a group of 19 patients treated surgically for vulvar carcinoma. We assessed the levels of these proteins by a series of measurements taken before and after the surgical intervention. The concentration levels of sRCAS1 and sHLA-G were established by means of ELISA kit. Results: In our study we observed that a statistically significant decrease in both sHLA-G and sRCAS1 blood serum concentration levels followed radical surgical intervention due to vulvar cancer. Conclusions: The detected levels of the blood serum concentration of these proteins may be a useful indicator of the status of the tumor microenvironment and may help to assess the degree of restoration of immune system activity following radical surgical vulvectomy.

Słowa kluczowe
vulvar cancer, sRCAS1, radical vulvectomy, sHLA-G, tumor microenvironment