Breast cancer is the most common malignant tumour developing in Polish women. Each year, over 11,000 new cases are registered in our country. Breast cancer is the leading cause of mortality due to malignant neoplasms in the females. The aim of paper, apart of presenting extremely advanced clinical cases of breast cancer and management strategies implemented, is to highlight the complexity of this problem, due overlapping of several medical and social factors. Inoperable, locally advanced breast cancer usually presents clinically as a giant primary tumour, frequently with extensive metastases in the axillary fossa. Giant breast tumour, with a diameter exceeding 5 cm, frequently extensively invading skin and deeper tissues, is usually accompanied by lymphatic oedema. Occurrence of such clinically advanced and morphologically gigantic forms of breast cancer in the material of Palliative Care Unit is most often due to one of the following: dynamic progression or recurrence of the disease, refusal of cause-oriented treatment or its interruption and extreme neglect. The main treatment option in this group of patients is aggressive induction chemotherapy. If surgery is contraindicated, patients undergo radical radiotherapy. Principal goal of therapy at a palliative care unit is relief of symptoms and improvement of quality of life, realized by medical and non-medical means. Psychological and spiritual support aims at creating a positive attitude of the patient towards his or her condition. The key factor is partner-like relations with patients, preservation of their autonomy and respect for their decisions concerning continuation of further treatment.