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Recurrence after surgical excision and radiotherapy in cervical cancer stage IB/IIA

J. Starzewski1,2, J. Sygut3, M. Malmur1, M. Klonowski1, J. Plutecki1, A. Chil1, M. Misiek1, L. Smorąg1, A. Wrona-Cyranowska1, K. Detka1, J. Krawczyk1, P. Kędzierawski4, A. Bąk-Dzierżyński1, T. Postuła1

Affiliacja i adres do korespondencji
GIN ONKOL 2007, 5 (3), p. 125-139
Streszczenie

Aim of paper: Analysis of clinical course of tumour recurrence in patients undergoing surgical excision and radiotherapy for FIGO stage IB/IIA cervical cancer and retrospective evaluation of selected clinical-pathological tumour features in the group of patients, who developed a recurrence, with particular emphasis on recurrence-associated risk factors based on the GOG (Gynaecologic Oncology Group) scale. Material and method: Retrospective analysis encompassed 107 women treated at the Świętokrzyskie Centrum Onkologii (Holycross Cancer Centre) since 2000 thru 2004. Results: Three-year symptom-free survival was obtained in 92 out of 107 women (85%). Recurrence occurred in 16 out of 107 patients (15%), thereof 9 out of 84 women (10%) originally had no lymph-node metastases and 7 out of 23 women (21%) had confirmed lymph node involvement. Recurrences were associated with lateral metastases (5 cases), distant metastases (7 cases) and lateral and distant metastases (4 cases). Recurrence-associated mortality rate was 81% (13 out of 16 patients). Currently, 3 women are alive, 2 thereof having signs of recurrence. Mean recurrence-free survival was 19.6 months and mean symptom-free survival was 8.5 months. Retrospective analysis based on the GOG scale predicted high risk of recurrence (over GOG score 120) in 14 out of 16 women (88%), who did recur and a moderate risk (GOG score 70-120) in the remaining 2 patients (12%). Conclusions: High risk of recurrence predicted by the GOG score has been confirmed in the group of women with cervical cancer FIGO stage IB/IIA undergoing combined treatment (surgery and radiotherapy) independent of invasion of regional lymph nodes. An essential risk factor for tumour recurrence is presence of tumour cells in pericervical and perivaginal tissues.

Słowa kluczowe
cervical cancer, surgical treatment, recurrence, recurrence risk evaluation based on GOG score, clinical course