Hypoxia in malignant tumors is associated with resistance to radio- and chemotherapy. Studies of patients with cervical cancer revealed a correlation between anoxia in tissues containing tumor cells and a worse 3-year survival rate. Assay of hypoxia markers: HIF-1α, CA 9 and GLUT 1 using immunochemical techniques in biopsy material or surgical specimens of uterine cervix represents a less invasive approach than assessment of hypoxia using the Eppendorf probe. Assessment of anoxia enable optimal tailoring of therapy and it’s monitoring. It is hoped, that YC-1 may have a favorable therapeutic effect by suppressing HIF-1α.