The connection between overall survival and the serum level of the cytokeratin 19 (CYFRA 21-1) fragments in 73 cervical cancer patients FIGO stage IB and IIA was analyzed. The measurement was performed before surgical treatment. The dependency of the CYFRA 21-1 serum level on the clinical stage, grading and the overall survival was investigated. In 38% cases the serum level before surgery was >2.5 pg/ml. In cases of lower concentration, longer overall survival was observed. The results of this study suggest that early cervical cancer patients with serum presence of cytokeratin 19 fragments before surgery need a complementary treatment.