The prognostic value of the cytokeratin 19 (CYFRA 21-1) fragments serum level in cervical cancer patients
Sławomir Terlikowski1, Andrzej Lenczewski1, Bożena Dobrzycka1, Oksana Kovalchuk2, Krzysztof Lejmanowicz1, Lech Chyczewski2, Jacek Nikliński3, Marek Kulikowski1
The connection between overall survival and the serum level of the cytokeratin 19 (CYFRA 21-1) fragments in 73 cervical cancer patients FIGO stage IB and IIA was analyzed. The measurement was performed before surgical treatment. The dependency of the CYFRA 21-1 serum level on the clinical stage, grading and the overall survival was investigated. In 38% cases the serum level before surgery was >2.5 pg/ml. In cases of lower concentration, longer overall survival was observed. The results of this study suggest that early cervical cancer patients with serum presence of cytokeratin 19 fragments before surgery need a complementary treatment.