Hormones and carcinogenesis. An Overview
Affiliation and adress for correspondence

Correspondence to: Zakład Biologii Molekularnej, Centrum Onkologii – Instytut im. Marii Skłodowskiej-Curie, ul. Roentgena 5, 02-781 Warszawa
Source of financing: Department own sources

GIN ONKOL, 2004, 2 (3), p. 139-146

Recent progress in biological research and in particular in molecular biology has contributed to better understanding of oncogenesis. Hormone-related cancers share a unique mechanism of carcinogenesis, mainly because exogenous and endogenous hormones drive cell proliferation in these tumors. As a result of increased proliferation, random gene alterations can accumulate. Unfortunately, most of the genes regulated by hormones are currently unknown. Finally, growing number of genetic errors creates a malignant phenotype. This review presents current knowledge about the interrelations between hormones and hormone-related cancers with breast cancer as an example.

Keywords: hormones, growth factors, hormone-dependant tumors, hormone-dependant regulation of proliferation, breast cancer