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The prognostic value of the WHO status in cervical cancer patients

Agnieszka Żółciak-Siwińska1, Joanna Jońska-Gmyrek2, Leszek Gmyrek3

Affiliacja i adres do korespondencji
Curr Gynecol Oncol 2015, 13 (2), p. 93–98
DOI: 10.15557/CGO.2015.0011
Streszczenie

Background/Aims: The pretreatment World Health Organization performance status in cervical cancer patients is very often underestimated. The aim of this study was to assess the World Health Organization performance status as a prognostic factor in patients with cervical cancer. Methods: A total of 142 cervical adenocarcinoma and 242 squamous cell cancer patients with FIGO stage I–IV were included in the retrospective analysis. All patients received surgical treatment and complementary radiotherapy or radiotherapy alone between January 1989 and December 1999. The multivariate Cox analysis, taking into account the clinical and histological factors, was performed. Results: The median age of patients was 54 years (range 25–85 years); the median follow-up time was 52 months (range 9–174 months). Regardless of other factors, the World Health Organization status (1–3 vs. 0) showed statistically significant association with the overall survival [HR= 2.5 (1.4, 4.5), p = 0.002] and the disease free survival [HR = 2.1 (1.2, 3.5), p = 0.005] in adenocarcinoma patients. No impact of the performance status on treatment outcomes was observed in patients with cervical squamous cell cancer. Conclusion: The World Health Organization performance status in cervical adenocarcinoma patients seems to be an important prognostic factor which may prove helpful in the qualification for an appropriate treatment.

Słowa kluczowe
cervical cancer, general condition, treatment outcomes