In the treatment of ovarian cancer, surgery, chemotherapy or possibly radiotherapy are applied. The scope of surgery is the most significant prognostic factor. Complete cytoreduction is the optimal surgical method. Most frequently, ovarian carcinoma does not involve only the reproductive system, but spreads throughout the peritoneal cavity. In some cases, splenic involvement is found during a surgery. In such cases the surgery should be supplemented with splenectomy – when the spleen is removed as an additional procedure during the operation or as an element of the en bloc removal of the tumor along with the omentum, colon and gastrocolic ligament. Such an extended operation results in only slightly increased number of complications and has no significant impact on the quality of life of ovarian cancer patients. It often enables full cytoreduction. Complications of this part of the operation predominantly include hemorrhage, thromboembolism, infection and, in the case of en bloc operation, anastomotic separation within the gastrointestinal tract. The data available report increased number of intraoperative blood transfusions. The procedure in question is most frequently carried out during a secondary cytoreductive surgery. Despite the lack of recommendations, such procedures should be performed by a surgical team experienced in operations in the upper abdominal cavity. The treatment should be complemented with state-of-the-art chemotherapy. This kind of treatment requires establishing a national network of oncological centers dealing with combined therapies of malignant neoplasms.