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Biochemical diagnostics of gynecological malignancies – what’s new?

Janina Kamińska1, Maria Kowalska1, Beata Kotowicz1, Małgorzata Fuksiewicz1, Alicja Siedlecka1, Mariusz Bidziński2

Affiliacja i adres do korespondencji
GIN ONKOL, 2006, 4 (1), p. 10-13
Streszczenie

The analysis of the utility of serum SCC determination, combined with other tumor markers and cytokine assessment in cervical cancer patients, was performed. However, only CA 125 levels were found to relate to the histopathological type of the tumor, and were higher in adenocarcinoma. In addition, in patients with adenocarcinoma, CA 125 presented higher diagnostic sensitivity than CEA, standard tumor marker for cervical cancer. We have also shown that complementary IL-6 and SCC assessment in patients with cervical cancer improve the diagnostic sensitivity, independent of histopathological type. This would be especially important for early diagnostics and monitoring of patients. We have also demonstrated the possible use of bone metabolism markers in patients after oncological treatment with posttreatment osteoporosis, which is a common side effect of cancer treatment. Actually, bone metabolism markers join the array of tumor markers, to monitor osteoporosis treatment. For the monitoring purposes, these markers are more efficient than densitometry methods. Our preliminary results on osteocalcin, PINP and Ctx point at PINP as the most promising marker.

Słowa kluczowe
tumor markers, cytokines, markers of bone turnover, cervical carcinoma, diagnostic sensitivity