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The evaluation of the treatment tolerance in cervical cancer patients, FIGO stage II and III, treated with radiotherapy in dependence on the brachytherapy method and the type of radioactive source used

Dariusz Kieszko1, Maria Mazurkiewicz2

Affiliacja i adres do korespondencji
GIN ONKOL, 2005, 3 (1), p. 22-32
Streszczenie

Introduction: The disadvantageous effect of the irradiation in cervical cancer patients is the radiation injury, especially in the bladder and rectum. Objective: The aim of the study was the assessment of the frequency and intensity of early and late radiation injury in dependency on the radioactive source and the brachytherapy method used in radical treatment of cervical cancer patients. Material and methods: The retrospective analysis of 314 cervical cancer patients FIGO II and III stage, treated with radiotherapy at the Gynecological Oncology Department at Centre of Oncology in Lublin was performed. The two groups of patients were separated. Group I – 148 women, treated between 1990 and 1992. In this group the brachyterapy was performed with the afterloading system, using radium or cesium as the radioactive source. Group II – constituted 166 women, treated between 1994 and 1996. In this group, the automatic afterloading system with cesium was used. Results: The percentage of early rectal and bladder sequelae was similar in both groups, and amounted for 43.92% in the group I, and 45.78% in the group II. The difference observed was not statistically significant (p=0.82). There was demonstrated, that early sequelae in both comparable groups more frequent appeared in rectum, than in bladder (p<0.0001). There was proved more frequent late radiation injury in the group I. Late radiation sequelae was noted among 34.46% of patients in the group I, and among 16.27% of patients in the group II. The difference was statistically significant (0.00033). Conclusions: The method of automatic afterloading with cesium is safer and causes less risk of late complications, than manual afterloading, using radium.

Słowa kluczowe
carcinoma of the uterine cervix, LDR brachytherapy, radiation therapy, early and late radiation complications