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The analysis of intestinal treatment – related sequelae in cervical cancer patients treated with radiotherapy

Ryszard Krynicki, Bogusław Lindner, Joanna Jońska, Krzysztof Gawrychowski, Grzegorz Panek, Mariusz Bidziński

Affiliacja i adres do korespondencji
GIN ONKOL, 2004, 2 (2), p. 100-106
Streszczenie

Introduction: External beam irradiation together with intracavitary irradiation is intended for delivering the total dose biologically active to cure cervical cancer locally. At the same time it causes the risk of radiation injury. The frequency of radiation complications is generally dependent on the type of the treatment performed. Objective: The factors which have influence on the frequency and the grade of the intestinal radiation complications were evaluated. Material and methods: The retrospective analysis of 1078 patients, treated between 1996 and 2000 at Gynecological Department of Oncological Center in Warsaw, was performed. The treatment consisted of the surgery and adjuvant radiotherapy or radiotherapy alone. The doses delivered with radiotherapy ranged from 41.4 to 46.2 Gy. If there were not conditions to perform the intracavitary radiotherapy, the dose was elevated up to 56-64 Gy. The intracavitary radiotherapy doses at point A were: 45-50 Gy. The Chi2 test to assess the relationship between the radiotherapy sequelae and the treatment-related and clinical-populate factors was performed. The Cox’ analysis was performed to assess the influence of the above factors on the late severe sequelae. Results: The early high grade sequelae were ascertained in 1.1%, late in 6% of patients. The early radiation injury are dependent on: the kind of surgical procedure, the time interval between the surgery and the start of adjuvant radiotherapy. The risk of late high grade sequelae is rising with FIGO stage and the total dose delivered with radiotherapy. Conclusions: The associated treatment, especially, the kind of the surgery performed and the time interval between surgery and adjuvant radiotherapy, plays a decisive role in the treatment tolerance. The risk of late radiation complications is dependent on the total dose and FIGO stage.

Słowa kluczowe
intestinal complications, radiotherapy, cervix carcinoma